{"id":15236,"date":"2025-08-21T13:54:26","date_gmt":"2025-08-21T16:54:26","guid":{"rendered":"https:\/\/redelitoralrs.com\/?p=15236"},"modified":"2025-08-21T13:54:27","modified_gmt":"2025-08-21T16:54:27","slug":"vacina-mostra-potencial-na-prevencao-e-no-tratamento-de-cancer-colorretal-e-de-pancreas","status":"publish","type":"post","link":"https:\/\/redelitoralrs.com\/index.php\/2025\/08\/21\/vacina-mostra-potencial-na-prevencao-e-no-tratamento-de-cancer-colorretal-e-de-pancreas\/","title":{"rendered":"Vacina mostra potencial na preven\u00e7\u00e3o e no tratamento de c\u00e2ncer colorretal e de p\u00e2ncreas"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Uma nova vacina experimental contra o c\u00e2ncer apresentou resultados promissores em pacientes com tumores no p\u00e2ncreas e na regi\u00e3o colorretal, segundo estudo publicado neste m\u00eas na revista <em>Nature Medicine<\/em>. O imunizante foi capaz de estimular respostas imunol\u00f3gicas duradouras, com potencial para reduzir a recorr\u00eancia da doen\u00e7a em pessoas de alto risco.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A pesquisa foi conduzida pelo Health Jonsson Comprehensive Cancer Center, da Universidade da Calif\u00f3rnia \u2013 Los Angeles (UCLA). O estudo avaliou a efic\u00e1cia da vacina em pacientes com muta\u00e7\u00f5es no gene <strong>KRAS<\/strong>, associado a aproximadamente 25% dos tumores s\u00f3lidos, incluindo 90% dos c\u00e2nceres de p\u00e2ncreas e 50% dos colorretais.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ap\u00f3s acompanhamento m\u00e9dio de 19,7 meses, os resultados indicaram sobrevida livre de recidiva de 16,3 meses e sobrevida global mediana de 28,9 meses, superando taxas hist\u00f3ricas para esse tipo de c\u00e2ncer, que costuma ter alta mortalidade e poucas op\u00e7\u00f5es terap\u00eauticas eficazes.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Como funciona a vacina<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">O imunizante, chamado <strong>ELI-002 2P<\/strong>, foi testado em 25 pacientes no ensaio cl\u00ednico de fase 1 AMPLIFY-201. Diferente de vacinas personalizadas, o produto \u00e9 padronizado e atua diretamente nos g\u00e2nglios linf\u00e1ticos, onde ativa respostas imunol\u00f3gicas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O estudo mostrou que <strong>84% dos pacientes desenvolveram c\u00e9lulas T espec\u00edficas contra muta\u00e7\u00f5es do KRAS<\/strong>, fundamentais para combater c\u00e9lulas tumorais. Em 24% dos casos, biomarcadores associados ao c\u00e2ncer desapareceram completamente. Pacientes que tiveram respostas imunol\u00f3gicas mais intensas permaneceram livres da doen\u00e7a por per\u00edodos mais longos.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Pr\u00f3ximos passos<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os resultados refor\u00e7am o potencial da vacina como uma alternativa inovadora no combate a tumores dif\u00edceis de tratar. A equipe respons\u00e1vel dar\u00e1 continuidade \u00e0s pesquisas em um ensaio cl\u00ednico maior, de fase 2, para confirmar a seguran\u00e7a e a efic\u00e1cia da abordagem.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uma nova vacina experimental contra o c\u00e2ncer apresentou resultados promissores em pacientes com tumores no p\u00e2ncreas e na regi\u00e3o colorretal, segundo estudo publicado neste m\u00eas na revista Nature Medicine. O imunizante foi capaz de estimular respostas imunol\u00f3gicas duradouras, com potencial para reduzir a recorr\u00eancia da doen\u00e7a em pessoas de alto risco. A pesquisa foi conduzida [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":15237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[247,15],"tags":[263,425,92,373],"class_list":["post-15236","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mundo","category-noticias","tag-cancer","tag-mundo","tag-noticia","tag-vacina"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Vacina mostra potencial na preven\u00e7\u00e3o e no tratamento de c\u00e2ncer colorretal e de p\u00e2ncreas - Rede Litoral RS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/redelitoralrs.com\/index.php\/2025\/08\/21\/vacina-mostra-potencial-na-prevencao-e-no-tratamento-de-cancer-colorretal-e-de-pancreas\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vacina mostra potencial na preven\u00e7\u00e3o e no tratamento de c\u00e2ncer colorretal e de p\u00e2ncreas - Rede Litoral RS\" \/>\n<meta property=\"og:description\" content=\"Uma nova vacina experimental contra o c\u00e2ncer apresentou resultados promissores em pacientes com tumores no p\u00e2ncreas e na regi\u00e3o colorretal, segundo estudo publicado neste m\u00eas na revista Nature Medicine. 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